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Case Report
Masticator space abscess in a 47-day-old infant
Eunhee Kim, Ju Hee Jeon, Yoon Hee Shim, Kyu-Seok Lee, So Young Kim, Eun Ryoung Kim
Clin Exp Pediatr. 2011;54(8):350-353.   Published online August 31, 2011

A 47-day-old male infant presented with fever, poor oral intake, irritability, and right-sided bluish buccal swelling. Contrast-enhanced computed tomography of the neck showed a round mass lesion of about 2.0×1.5 cm that suggested abscess formation in the right masticator space. Ultrasound-guided extraoral aspiration of the abscess at the right masseter muscle was successful. Staphylococcus aureus was identified in the culture...

Original Article
The relationship between catechol-O-methyltransferase gene polymorphism and coronary artery abnormality in Kawasaki disease
Hyo Jin Lee, Myung Sook Lee, Ji Sook Kim, Eun Ryoung Kim, Sung Wook Kang, Soo Kang Kim, Joo Ho Chun, Kyung Lim Yoon, Mi Young Han, Seong Ho Cha
Clin Exp Pediatr. 2009;52(1):87-92.   Published online January 15, 2009
Purpose : Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O- methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT...
Glutathione S-transferase polymorphism of neonatal hyperbilirubinemia in Korean neonates
Chang Seok Kang, Seung Su Hong, Ji Sook Kim, Eun Ryoung Kim
Clin Exp Pediatr. 2008;51(3):262-266.   Published online March 15, 2008
Purpose : Glutathione S-transferase (GST) is a polymorphic supergene family of detoxification enzymes that are involved in the metabolism of numerous diseases. Several allelic variants of GSTs show impaired enzyme activity and are suspected to increase the susceptibility to diseases. Bilirubin is bound efficiently by GST members. The most commonly expressed gene in the liver is GSTM1, and GSTT1 is...
The relationship between Gly71Arg and TATA box polymorphism of UGT1A1 gene and prolonged hyperbilirubinemia of breast milk feeding infant in Korean
Jae Myoung Lee, Young Ji Han, Ji Sook Kim, Eun Ryoung Kim
Clin Exp Pediatr. 2008;51(2):150-155.   Published online February 15, 2008
Purpose : It has been known that breast milk cause prolonged unconjugated hyperbilirubinemia. UGT1A1 is a important gene of uridine diphosphate glucuronosyltransferase (UGT) which has a major role of bilirubin metabolism. These findings suggest that there is a relationship between UGT1A1 gene mutation and prolonged jaundice of breast feeding infant. The aim of study was to investigate whether a polymorphism...
The relation between angiotensin converting enzyme (ACE) gene polymorphism and neonatal hyperbilirubinemia in Korea
Mi Yeoun Kim, Jae Myoung Lee, Ji Sook Kim, Eun Ryoung Kim, Hee Jae Lee, Seo Hyun Yoon, Joo Ho Chung
Clin Exp Pediatr. 2007;50(1):28-32.   Published online January 15, 2007
Purpose : Human angiotensin converting enzyme (ACE) gene shows an insertion/deletion polymorphism in 16 intron, and three genotypes are determined by whether a 287 bp fragment of the DNA is present or not; II, ID and DD genotype. DD genotype has been suggested as a risk factor of chronic nephrotic disease such as IgA nephropathy and diabetic nephropathy, various cardiovascular...
Case Report
A case of congenital neurocutaneous melanosis
Sang Kyun Ha, Jae Myoung Lee, Eun Ryoung Kim, Ho Hwang, Hong Tak Lee
Clin Exp Pediatr. 2006;49(2):212-216.   Published online February 15, 2006
Neurocutaneous melanosis is a rare congenital syndrome characterized by the presence of large or multiple congenital melanocytic nevi and benign pigment cell tumors of the leptomeninges. Neurocutaneous melanosis is thought to represent an error in the morphogenesis of embryonal neuroectoderm. We experienced a neonate who presented with giant, dark colored pigmented nevi covering chest, abdomen, neck and arms, with satellite...
Original Article
1828G>A polymorphism of the UDP-glucuronosyltransferase gene (UGT1A1) for neonatal hyperbilirubinemia in Koreans
Ja Young Kim, Mi Yeoun Kim, Ji Sook Kim, Eun Ryoung Kim, Seo Hyun Yoon, Hee Jae Lee, Joo Ho Chung
Clin Exp Pediatr. 2006;49(1):34-39.   Published online January 15, 2006
Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in Caucasians. However, its metabolic basis has not been clearly explained. The UDP-glucuronosyltransferase gene(UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia. We studied whether neonatal hyperbilirubinemia is associated with the 1828G>A(rs 10929303) polymorphism of the UGT1A1 gene, which encodes for a...
The Association of Neonatal Hyperbilirubinemia with UGT1A1 and CYP1A2 Gene Polymorphism in Korean Neonates
Hoon Kang, Jun Ho Lim, Ji Sook Kim, Eun Ryoung Kim, Sung Do Kim, Hee Jae Lee, Joo Ho Chung
Clin Exp Pediatr. 2005;48(4):380-386.   Published online April 15, 2005
Purpose : The incidence of nonphysiologic neonatal hyperbilirubinemia is twice as high in East Asians as in whites. Recently, UGT1A1 mutation was found to be a risk factor for neonatal hyperbilirubinemia. In congenitally-jaundiced Gunn rats, which lack expression of UDP-glucuronosyltransferase, alternative pathways can be stimulated by inducers of CYP1A1 and CYP1A2 enzymes. CYP1A2 plays a major role in bilirubin degradation...
Study of Exchange Phenomenon of Mycoplasma pneumoniae in Children from 1997-2002
Sung Seok Kim, Hoon Kang, Byung Moon Ahn, Won Wook Lee, Eun Ryoung Kim, Soo Yeon Kim, Hyun Pil Cho
Clin Exp Pediatr. 2004;47(1):24-30.   Published online January 15, 2004
Methods : We enrolled 504 patients out of 547 patients, who were admitted to the Department of Pediatrics, Sung-Ae and Kwangmyung Sung-Ae General Hospital from November 1996 to October 2002. They were diagnosed as M. pneumoniae pneumonia by clinical characteristics and indirect particle agglutination test of M. pneumoniae. To classify into two groups, the group specific polymerase chain reaction amplification...
Polymorphism of UDP-glucuronosyltransferase Gene(UGT1A1) of Neonatal Hyperbilirubinemia in Korea
Ki Woong Hong, Hoon Kang, Soo Kim, Ji Sook Kim, Eun Ryoung Kim, Hee Jae Lee, Sheng-Yu Jin, Joo Ho Chung
Clin Exp Pediatr. 2004;47(1):18-23.   Published online January 15, 2004
Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in whites and its metabolic basis has not been clearly explained. Recently, UDP-glucuronosyltransferase gene (UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia in Japanese and Taiwanese Chinese. We studied whether neonatal hyperbilirubinemia is associated with mutation of UGT1A1, which is a...
Case Report
A Case of Recurrent Herpes Simplex Virus Disease of a Preterm Infant, Who Needed Continuous Oral Acyclovir Suppressive Therapy
Sung Seok Kim, Ki Woong Hong, Eun Ryoung Kim, Young-Don Kim, Kyoo Man Lee
Clin Exp Pediatr. 2003;46(9):939-949.   Published online September 15, 2003
Neonatal herpes simplex virus(HSV) infections result in significant morbidity and mortality. Although acyclovir treatment has improved survival, severe neurological sequelae can occur in the majority of survivors. HSV infections limited to the skin, eyes and mouth(SEM) can cause neurologic impairment. A direct correlation exists between the development of neurologic deficits and the frequency of cutaneous HSV recurrences. National Institutes of...
Original Article
Diagnostic Value of 99mTc-DMSA Pinhole Imaging in Childhood Urinary Tract Infection with Renal Cortical Defect
Tae Won Lee, Seung Jun Seong, Byung Moon Ahn, Ie Ryung Yoo, Il Soo Kim, Eun Ryoung Kim, Sung Hoon Kim, Yong-Whee Bahk
Clin Exp Pediatr. 2002;45(1):72-78.   Published online January 15, 2002
Purpose : The aim of this study was to assess the diagnostic value of the 99mTc-DMSA pinhole imaging by comparing the detection rate of cortical defects identified from planar and pinhole imaging. Methods : 99mTc-DMSA planar and pinhole imaging, voiding cystoureth-rogram(VCUG), renal ultrasonography were performed in 67 patients diagnosed with urinary tract infection at the Department of Pediatrics, Sung-Ae General Hospital, from September, 1999 to...
Case Report
A Congenital Cutis Laxa Fatality Caused by Early Onset Pulmonary Emphysema
Tae Won Lee, Seung Jun Seong, Yoo Mi Jeung, Jae Bok Kim, Eun Ryoung Kim, Yong Su Yoon
Clin Exp Pediatr. 2001;44(10):1176-1181.   Published online October 15, 2001
Cutis laxa is a rare disorder of the elastic tissue characterized by loosely hanging and folded skin giving a premature senile appearance, often with internal organ involvement. Recently, we experienced a case of cutis laxa in a neonate. The patient who presented with dyspnea and loose skin at birth was delivered by Cesarean section in our hospital. He was the...
A Case of Neonatal Alloimmune Thrombocytopenia due to Anti-HLA A2
Sung Young Kim, Eun Ryoung Kim, Young Jin Kim, Myoung Hee Park, Eun Young Song, Kyou Sup Han
Clin Exp Pediatr. 2000;43(6):861-865.   Published online June 15, 2000
Neonatal alloimmune thrombocytopenia(NAIT) is a rare disease caused by maternal alloimmunization against fetal platelet surface antigen, which is mainly platelet specific alloantigen or human leukocyte antigen(HLA). During routine hemotology, we accidentally discovered thrombocytopenia in a female fullterm newborn admitted due to jaundice. We excluded NAIT due to human platelet alloantigen(HPA), because the HPA of the mother and baby were the...
Original Article
Early Diagnosis of Rifampin-Resistant Mycobacterium tuberculosis by Gene Analysis of RNA Polymerase B Subunit
Ki Seok Park, Nam Soo Park, Eun Ryoung Kim, Seok Ho Choi, Hyun Phil Cho, Young Ho Moon, Il Soo Kim
Clin Exp Pediatr. 1999;42(10):1403-1411.   Published online October 15, 1999
Purpose : The control of tuberculosis is seriously threatened worldwide by the recently emerging multidrug-resistant Mycobacterium tuberculosis. As a result, early detection of drug resistant M.tuberculosis strain has become very important but conventional laboratory methods are time consuming and delayed results often affect patients adversely in controlling tuberculosis. The authors studied the usefulness of the line probe assay to determine...
Case Report
A Case of Split Hand Split Foot Anomaly
Mi Do Lee, Byung Moon Ahn, Moo Young Song, Eun Ryoung Kim, Mi Wook Jin, Il Soo Kim
Clin Exp Pediatr. 1999;42(7):1008-1013.   Published online July 15, 1999
We experienced a case of split hand split foot(SHSF) anomaly in a male neonate who had a deficiency of the middle finger, syndactyly of the 1st and 2nd finger and a deep median cleft in both hands. He also had a deep median cleft between 2nd and 3rd toe, syndactyly of the 1st and 2nd, 3rd and 4th toe without...
A Case of Congenital Self-Healing Reticulohistiocytosis
Taek Sun Kim, Chang Wan Kim, Eun Ryoung Kim, You Mee Kang, Kye Yong Song
Clin Exp Pediatr. 1998;41(10):1424-1429.   Published online October 15, 1998
Congenital self-healing reticulohistiocytosis(CSHR) is a rare variant of cutaneous reticulohistiocytosis. We report a newborn who had about 25 reddish brown papulonodular lesions on whole body at birth. No extracutaneous involvement was found. All skin lesions involuted within 4 months spontaneously. Biopsy of a skin lesion showed marked aggregated histiocytic infiltration with some eosinophils. S-100 protein and lysozyme were positive. Electron...
Original Article
The Diagnostic Value of Polymerase Chain Reaction in Mycoplasma pneumoniae Pneumonia
Han Wook Kang, Byung Moon Ahn, Moo Young Song, Eun Ryoung Kim, Suk Ho Choi, Il Soo Kim
Clin Exp Pediatr. 1998;41(10):1351-1358.   Published online October 15, 1998
Purpose : This study was performed to evaluate the polymerase chain reaction(PCR) in the diagnosis of Mycoplasma pneumoniae pneumonia in comparison with the specific antibody test. Methods : Five hundred and ten patients with pneumonia, ranging from the ages of 8 months to 15 years who were admitted in Sung-Ae and Kwangmyung Sung-Ae general hospitals from Nov. 1996 to Oct....
Case Report
A Case of 2q＋ Syndrome Identified by Fluorescent In Situ Hybridization
Hong Hee Lim, Soo Sung Park, Jong Won Lee, Eun Ryoung Kim, Mi Uk Jin, Nam Soo Park, IL Soo Kim
Clin Exp Pediatr. 1998;41(8):1144-1148.   Published online August 15, 1998
Original Article
Rapid Identification of Mycoplasma Pneumoniae, Mycobacterium Tuberculosis and Staphylococcus Aureus in Pleural Fluid by PCR
Chang Wan Kim, Byung Moon Ahn, Eun Ryoung Kim, Il Su Kim, Yung Seuk Pak, Sang Chul Sung
Clin Exp Pediatr. 1997;40(9):1232-1241.   Published online September 15, 1997
Purpose : Pleural effusions may develop during the course of bacterial pneumonia. The aim of this study was to evaluate the significance of the polymerase chain reaction(PCR) method for detection of M ycoplasma pneumoniae, M ycobaterium tuberculosis and Staphylococcus aureus from pleural fluid. Methods : Total 12 samples were obtained from pleural fluid; 2 samples from children with Mycoplasma pneumonia, 5 samples from adults with...
Case Report
Acute Renal Failure(ARF) Associated with Yersinia Pseudotuberculosis Infection Diagnosed by Polymerase Chain Reaction
Hyung Gyu Park, Byung Moon Ahn, Eun Ryoung Kim, Il Soo Kim, Jae Jong Kim, Sung Ok Kang, Han Ho Park, Ki Jeong Kim
Clin Exp Pediatr. 1997;40(8):1162-1168.   Published online August 15, 1997
The clinical significance of Yersinia pseudotuberculosis(Y. pseudotuberculosis) has recently recognized in various part of the world because it can cause a wide range of clinical problems such as mesenteric lymphadenitis, septicemia, reactive arthritis, terminal ileitis, erythema nodosum and acute renal failure. we experienced a case of acute renal failure associated with Y. pseudotuberculosis infection. We applied a nested polymerase chain reaction method for rapid diagnosis...
Original Article
Peripheral-Blood-Based PCR Assay to Identify Patients with Childhood Tuberculosis
Soo Sung Park, Byoung Moon Ahn, Eun Ryoung Kim, Il Soo Kim, Jae Jong Kim, Yu Jin Rha, Han Ho Park
Clin Exp Pediatr. 1997;40(6):841-849.   Published online June 15, 1997
Purpose : There is an urgent need for rapid and accurate diagnosis of childhood tuberculosis. Recently, developments in molecular biology have raised hopes about the possibilities of new strategies for tuberculosis diagnosis. Most of these methods have focused on the application of PCR to sputum samples from patients with suspected mycobacterial disease. We used a nested PCR to detect circuclating Mycobacterial tuberculosis DNA in...
Case Report
A Case of 3p Partial Trisomy
Jeong Eun Park, Il Soo Kim, Moo Young Song, Eun Ryoung Kim, Shin Young Moon, Sun Kyung Oh
Clin Exp Pediatr. 1996;39(6):873-880.   Published online June 15, 1996
3p partial trisomy is a rare chromosomal anomaly. We experienced a case of 3p partial trisomy in a male neonate. It was diagnosed by clinical and chromosoaml study. He had multiple anomalies such as brachycephaly, wide open fontanelle, square face, hypertelorism, mongoloid palpebral fissure, micrognathia, low set malformed ear, bilateral cleft lip and palate, double outlet right ventricle, atrial septal defect,...
An Autopsy Case of Double Aortic Arch
Ji Sook Kim, Yong Myung Jo, Kyung Hee Ko, Eun Ryoung Kim, Je Grun Chi
Clin Exp Pediatr. 1996;39(5):727-731.   Published online May 15, 1996
Double aortic arch is the most common type of symptomatic vascularring. In most patients, the symptoms are manifested at birth or in early infancy. Double aortic arch usually has more severe symptoms than other types of complete vascular rings. We experienced one case of complete duplicated double aortic arch with left descending aorta and left patent ductus arteriosus. A one-day-old female neonate was transferred...
Original Article
β2-Microglobulin is a Sensitive Marker for Predicting Renal injury in Childhood Urinary Tract Infection
Won Uk Lee, Byung Moon An, IL Soo Kim, Eun Ryoung Kim
Clin Exp Pediatr. 1996;39(5):665-672.   Published online May 15, 1996
Purpose : Urinary tract infection(UTI) in children may be cause of end stage renal failure and hypertension. So, early detection of renal scar, vesicoureteral reflux(VUR) and anomaly, and proper management are important. We carried this study to observe the significance of 24 hours urine β2-microglobulin(β2-MG) for predicting renal injury and correlation of β2-MG with the grade of VUR. Methods : We...
Case Report
One Case of Ruptured Aneurysm of Vein of Galen
Nam Soo Park, Moo Young Song, Un Jun Hyoung, Jin Oh Lee, Eun Ryoung Kim
Clin Exp Pediatr. 1992;35(5):691-695.   Published online May 15, 1992
The vein of Galen malformation is rare midline intracranial arteriovenous malformation that have been diagnosed more often at necropsy than in life. The majority of these malformations were seen in neonate, infancy and childhood, and the clinical symptoms and prognosis were depended on age of presentation. The authors report a case of ruptured Vein of Galen aneurysmal malformation. A...
Original Article
Two cases of Goldenhar syndrome.
Moo Young Song, Min Sik Kim, Nam Soo Park, Un Jun Hyoung, Jin Oh Lee, Eun Ryoung Kim
Clin Exp Pediatr. 1991;34(5):730-735.   Published online May 31, 1991
Goldenhar syndrome is a pattern of malformation with wide variability of expression characterized by epibulbar dermoids, preauricular appendages and pretragal blind-ended fistulas, and vertebral anomalies. We have experienced two cases of Goldenhar syndrome. In one case multiple hemivertebrae, anomalous ribs, hydrocephalus with abscence of the septum pellucidum and mild widening of the subarachnoid space were noted. Diagnosis was made by physical examination and radiological findings. A brief...
A Case of Chronic Relepsing Pancreatitis with Calcification in Childhood.
Yo Han Kim, Min Sik Kim, Moo Young Song, Eun Ryoung Kim, Jong Duk Lee, Soon Jai Lee
Clin Exp Pediatr. 1990;33(3):398-403.   Published online March 31, 1990
A 9-vear-old girl presented with recurrent abdominal pain. Investigations failed to show any of the demonstrable causes of pancreatitis, but she was found to have pancreatic calcifications with the help of the plain abdominal x-ray, abdominal ultrasound and abdominal C—T scan. Pancreatic calcifications are virtually pathognomonic of chronic pancreatitis. We report this case and review related literatures briefly.
Case Report
A Case of Potter Syndrome Associated with Renal Dysplasia.
Young Woo Park, Joon Ho Kim, Eun Ryoung Kim, Soon Jae Lee, Young Chul Moon, Young Jin Kim
Clin Exp Pediatr. 1987;30(7):812-817.   Published online July 31, 1987
Potter syndrome is relatively rare congenital defect in with agenesis or dysplasia of the kidney is associated with oligohydramnios, pulmonary hypoplasia, characteristic facial features and other abnormalities. The etiology is unknown. But various theories are reviewed and the suggestion is made that the cause of Potter syndrome in newborns may well be multifactorial. Among the various factors, we agree to the opinion that oligohydramnios...
A Case of Nodular Renal Blastema.
Sun Hee Kim, Yong Woo Park, Eun Ryoung Kim, Soon Jai Lee, Young Chul Moon, Young Jin Kim
Clin Exp Pediatr. 1986;29(7):803-819.   Published online July 31, 1986
We experienced a case of nodular renal blastema which was accompanied with bilateral renal dysplasia and cytomegalic inclusion disease. The patient who was born with 38 weeks of gestational periods and had had a omphalocele since birth expired on the 30 th day of his life. Autopsy was performed to confirm the diagnosis. We reported clinical and laboratory data of this case...
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